Molecular Imaging of Synaptic Loss in Multiple System Atrophy (MSA)
Groundbreaking research into MSA – Can you help?
A team at the University of Exeter are working on a groundbreaking study into the synoptic loss in MSA and are actively looking for people with MSA to take part.
Patients with MSA are found to have a build-up of a protein, called alpha-synuclein, in several areas of their brain. This protein collects close to the brain cells, which provide support and insulation to nerve cells. The exact way that alpha-synuclein accumulation leads to the gradual breakdown of neurons, causing the symptoms of the disease, is still unclear. However, we know that even before these cells die there is a loss of synapses (the structure which allows brain cells to send messages to other brain cells and across the brain) and a decrease in the metabolism of glucose, which is used as a measure of brain activity. By use of Positron Emission Tomography (PET), it is possible to determine the loss of synapses and the decrease of glucose metabolism. In this study, we aim to use PET imaging specific for measuring synapses and glucose metabolism, to investigate their role in disease progression in people with MSA.
If you are interested in taking part, please email firstname.lastname@example.org or call Holly Wright on 01392 722935 to find out more.
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