MSA Trust

MSA Trust funded research

Listed here are research papers produced by researchers that have received MSA Trust funding for research projects:

2008: Prof Tamas Revesz and Dr. Janice Holton, UCL Institute of Neurology, awarded £60,000 for a year study into ‘The role of p25a in Glial Cytoplasmic Inclusion’ formation.

LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions. Huang Y, Song YJ, Murphy K, Holton JL, Lashley T, Revesz T, Gai WP, Halliday GM. (2008) Acta Neuropathol. 2008 Dec;116(6):639-46

Clinical outcomes of progressive supranuclear palsy and multiple system atrophy. O’Sullivan SS, Massey LA, Williams DR, Silveira-Moriyama L, Kempster PA, Holton JL, Revesz T, Lees AJ. (2008) Brain. 2008 131:1362-1372

Neuropathology underlying clinical variability in patients with synucleinopathies. Halliday GM, Holton JL, Revesz T, Dickson DW. Acta Neuropathol. (2011)Aug;122(2):187-204

2009: Dr Janice Holton awarded £179,502 to study ‘Central Role of Oligodendroglia in pathogenesis of multiple system atrophy’.

Identification and quantification of oligodendrocyte precursor cells in multiple system atrophy, progressive supranuclear palsy and Parkinson’s disease. Ahmed Z, Asi YT, Lees AJ, Revesz T, Holton JL. Brain Pathol. (2013) May;23(3):263-73

Review: The neuropathology, pathophysiology and genetics of multiple system atrophy. Ahmed Z, Asi YT, Sailer A, Lees AJ, Houlden H, Revesz T, Holton JL. Neuropathol Appl Neurobiol. (2012) 38(1):4-24

Alpha-synuclein mRNA expression in oligodendrocytes in MSA. Asi YT, Simpson JE, Heath PR, Wharton SB, Lees AJ, Revesz T, Houlden H, Holton JL. Glia. (2014) 2014 Jun;62(6):964-70

2012: Dr Janice Holton, Honorary Consultant and Reader in Neuropathology at UCL Institute of Neurology. Awarded £100,000 for the project ‘Neuroinflammation in multiple system atrophy: A neuropathological study’ (a 2 year study).

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy? Kiely AP, Asi YT, Kara E, Limousin P, Ling H, Lewis P, Proukakis C, Quinn N, Lees AJ, Hardy J, Revesz T, Houlden H, Holton JL Acta Neuropathol. (2013) May;125(5):753-69

Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation. Kiely AP, Ling H, Asi YT, Kara E, Proukakis C, Schapira AH, Morris HR, Roberts HC, Lubbe S, Limousin P, Lewis PA, Lees AJ, Quinn N, Hardy J, Love S, Revesz T, Houlden H, Holton JL. Mol Neurodegener. 2015 Aug 27;10:41. doi: 10.1186/s13024-015-0038-3.

Immunohistochemical and Molecular Investigations Show Alteration in the Inflammatory Profile of Multiple System Atrophy Brain. Kiely AP, Murray CE, Foti SC, Benson BC, Courtney R, Strand C, Lashley T, Holton JL. J Neuropathol Exp Neurol. 2018 Jul 1;77(7):598-607

July 2013: Dr Janice Holton, Honorary Consultant and Reader in Neuropathology at UCL Institute of Neurology. Awarded £62,441 for the study of ‘The role of CoQ2 in multiple system atrophy’.

Coenzyme Q10 Levels Are Decreased in the Cerebellum of Multiple-System Atrophy Patients. Schottlaender LV, Bettencourt C, Kiely AP, Chalasani A, Neergheen V, Holton JL, Hargreaves I, Houlden H. PLoS One. 2016 Feb 19;11(2):e0149557

Cerebral mitochondrial electron transport chain dysfunction in multiple system atrophy and Parkinson’s disease. Foti SC, Hargreaves I, Carrington S, Kiely AP, Houlden H, Holton JL. Sci Rep. 2019 Apr 25;9(1):6559. doi: 10.1038/s41598-019-42902-7

2015: Professor Janice Holton Professor in Neuropathology, Director of Neuropathology, Queen Square Brain Bank, UCL Institute of Neurology, awarded £124,440, ‘Understanding the degradation of alpha-synuclein protein in Multiple System Atrophy’

Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of α-synuclein in multiple system atrophy. Kiely AP, Miners JS, Courtney R, Strand C, Love S, Holton JL. Neuropathol Appl Neurobiol. 2019 Jun;45(4):347-360

2018: Professor Janice Holton Professor in Neuropathology, Director of Neuropathology, Queen Square Brain Bank, UCL Institute of Neurology, awarded £129,270 for ‘Understanding selective brain regional vulnerability in multiple system atrophy’

White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy. Bettencourt C, Foti SC, Miki Y, Botia J, Chatterjee A, Warner TT, Revesz T, Lashley T, Balazs R, Viré E, Holton JL. Acta Neuropathol. 2020 Jan;139(1):135-156

Epigenomics and transcriptomics analyses of multiple system atrophy brain tissue supports a role for inflammatory processes in disease pathogenesis. Bettencourt C, Piras IS, Foti SC, Talboom J, Miki Y, Lashley T, Balazs R, Viré E, Warner TT, Huentelman MJ, Holton JL. Acta Neuropathol Commun. 2020 May 14;8(1):71

Transcriptional profiling of multiple system atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the disease. Piras IS, Bleul C, Schrauwen I, Talboom J, Llaci L, De Both MD, Naymik MA, Halliday G, inclusions Bettencourt C, Holton JL, Serrano GE, Sue LI, Beach TG, Stefanova N, Huentelman MJ. Acta Neuropathol Commun. 2020 Jun 3;8(1):76MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic implicated in the disease pathogenesis. Bettencourt C, Miki Y, Piras IS, de Silva R, Foti SC, Talboom JS, Revesz T, Lashley T, Balazs R, Viré E, Warner TT, Huentelman MJ, Holton JL. Neuropathol Appl Neurobiol. 2020 Dec 23. doi: 10.1111/nan.12688. Online ahead of print