MSA Trust

The SEQUOIA Study

Do you suffer from dizziness, light-headedness and feeling faint?

The SEQUOIA Study is a clinical research study looking at an investigational drug called ampreloxitine (also known as TD-9855), for people with Multiple System Atrophy (MSA). Upon standing, some people with MSA experience dizziness, light-headedness, feeling faint, or feeling like they might black out due to a drop in blood pressure. Researchers want to learn whether ampreloxitine can reduce these symptoms and assess how safe it is.

If you suffer symptoms such as these and are 30 years of age or older you may be able to take part.

The SEQUOIA Study lasts up to 7 weeks and it is made up of:

  • 2-3 week screening period where assessments will be performed to determine your eligibility and for you to decide whether you want to take part.
  • 4 weeks of taking the study medication (either the investigational drug or placebo/dummy drug) by mouth once daily. You will also visit the study centre for study assessments.
  • Upon completion of the SEQUOIA Study, you are eligible to join another related study lasting up to 22 weeks if you wish.

Want to know more?  Please see the table below of the current open sites.  It is hoped that other sites might become available over the next few months, so please keep checking back. By making contact, you are under no obligation to take part. Our MSA Trust Nurse Specialist are happy to discuss this study with you, however it is important to first discuss with the study centre about the possibility of taking part.

Project Site NamePrincipal InvestigatorContact Details for enquiriesCountyCity MSA Nurse Specialist
The National Hospital for Neurology & NeurosurgeryValeria IodiceScott Johnstone: 07910 591343 or 0203 448 3470; scott.johnstone@nhs.netGreater LondonLondon 

Samantha Pavey

0203 371 0003

Barts HospitalManish SaxenaDr Manish Saxena: 0207 882 3856; m.saxena@qmul.ac.ukGreater LondonLondon 

Samantha Pavey

0203 371 0003

Royal Devon and Exeter Hospital (Wonford)Raymond SheridanRob James: 01392 408145DevonExeter 

Jill Lyons

01934 316119

Re:Cognition Health (Plymouth)Steve PearsonGeorge Robinson: 01752 712046; grobinson@re-cognitionhealth.comDevonPlymouth 

Jill Lyons

01934 316119

Re:Cognition Health Ltd (London)Josephine MacSweeneyGeorge Robinson: 0203 808 5439 ; grobinson@re-cognitionhealth.comGreater LondonLondon 

Samantha Pavey

0203 371 0003

Salford Royal NHS Foundation TrustChristopher Kobylecki 

Liam McMorrow: 01612 067293; liam.mcmorrow@srft.ns.uk

Greater ManchesterManchester 

 

Emma Saunders

0330 221 1030

Re:Cognition Health Ltd (Birmingham)Karen FaulknerGeorge Robinson: 0121 468 2045; grobinson@re-cognitionhealth.comWest MidlandsBirmingham 

Emma Saunders

0330 221 1030

 

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