MSA Trust

Current Research Opportunities

The Multiple System Atrophy Trust supports ongoing research in neuroscience, neurology clinical practice and is developing a database to support researchers to develop their research further.

Multiple System Atrophy is a very complex disease and work to find the cause and ultimately a cure is equally complex and may take many years, but the Trust is committed to funding research for as long as it takes. The Trust has a clear remit outlined in it’s research strategy for the type of project it will consider:

  • Funding for projects aimed at finding the cause of MSA and improving treatments for those with MSA.
  • Collaborative partnerships with other organisations involved in neurodegenerative research
  • Encouraging engagement with the pharmaceutical industry

Do you suffer from dizziness, light-headedness and feeling faint?

 

 

The SEQUOIA Study is a clinical research study looking at an investigational drug called ampreloxitine (also known as TD-9855), for people with Multiple System Atrophy (MSA). Upon standing, some people with MSA experience dizziness, light-headedness, feeling faint, or feeling like they might black out due to a drop in blood pressure. Researchers want to learn whether ampreloxitine can reduce these symptoms and assess how safe it is.

If you suffer symptoms such as these and are 30 years of age or older you may be able to take part.

The SEQUOIA Study lasts up to 7 weeks and it is made up of:

  • 2-3 week screening period where assessments will be performed to determine your eligibility and for you to decide whether you want to take part.
  • 4 weeks of taking the study medication (either the investigational drug or placebo/dummy drug) by mouth once daily. You will also visit the study centre for study assessments.
  • Upon completion of the SEQUOIA Study, you are eligible to join another related study lasting up to 22 weeks if you wish.

Want to know more?  Please see the table below of the current open sites.  It is hoped that other sites might become available over the next few months, so please keep checking back. By making contact, you are under no obligation to take part. Our MSA Trust Nurse Specialist are happy to discuss this study with you, however it is important to first discuss with the study centre about the possibility of taking part.

Project Site NamePrincipal InvestigatorContact Details for enquiriesStateCity MSA Nurse Specialist
The National Hospital for Neurology & NeurosurgeryValeria IodiceScott Johnstone: 07910 591343  or 0203 448 3470; scott.johnstone@nhs.netGreater LondonLondon 

Samantha Pavey

0203 371 0003

Barts HospitalManish SaxenaDr Manish Saxena: 0207 882 3856; m.saxena@qmul.ac.ukGreater LondonLondonSamantha Pavey

0203 371 0003

Royal Devon and Exeter Hospital (Wonford)Raymond SheridanRob James: 01392 408145DevonExeterJill Lyons

01934 316119

Re:Cognition Health (Plymouth)Steve PearsonGeorge Robinson: 01752 712046; grobinson@re-cognitionhealth.comDevonPlymouth 

Jill Lyons

01934 316119

Re:Cognition Health Ltd (London)Josephine MacSweeneyGeorge Robinson: 0203 808 5439 ; grobinson@re-cognitionhealth.comGreater LondonLondon 

Samantha Pavey

0203 371 0003

Re:Cognition Health Ltd (Birmingham)Karen FaulknerGeorge Robinson: 0121 468 2045 ;grobinson@re-cognitionhealth.comWest MidlandsBirmingham 

Emma Saunders

0330 221 1030

 

MSA Trust is accepting new and innovative project grant applications for our Research Grant Round 2019

Applications Open: 1st September 2019

At Multiple System Atrophy Trust, we are committed to funding the best scientific research so that we can get a step closer to discovering the cause and cure of multiple system atrophy (MSA).

We intend to further increase our knowledge and understanding of MSA by supporting researchers with a new round of grant funding in 2019/20.  MSA Trust seeks innovative and translational neuroscience research projects. We are open to working collaboratively, at home and abroad, where there is a demonstrable connection to a UK-based Principal Investigator/Institution.  We welcome grant funding applications up to the value of £150,000.  Applications can be for single or multiple years’ projects.

We welcome research grant applications on any aspect of basic, translational or clinical neuroscience, aimed at better understanding the cause and/or improving treatment of MSA.  The applications will be reviewed by our Scientific Advisory Panel, chaired by Dr. Christopher Kobylecki, Salford Royal Hospital. Criteria for application is given on our website https://www.msatrust.org.uk/cause-and-cure/ In this section of the website you will find updated guidelines for application, our research strategy, terms and conditions and an application form.

Closing Date for applications is 30th November 2019, 5p.m. 

All applications should be sent along with any supporting materials to Karen.walker@msatrust.org.uk

The Sir Roger Bannister Clinical Research Training Fellowship

A funded partnership between Multiple System Atrophy Trust (MSAT) and the Association of British Neurologists (ABN)

 

MSA Trust are pleased to announce a further opportunity for a prestigious ABN Clinical Research Training Fellowship in the study of Multiple System Atrophy (MSA).

This year the fellowship will be awarded in memory of Sir Roger Bannister CH CBE FRCP, who as a former Chairman of the MSA Trust Research Committee and a Patron of MSA Trust for many years, was committed to further research into MSA.

Sir Roger dedicated a lifetime to neurology and in particular to understanding the causes of autonomic failure. This fellowship, in his name, offers one Fellow the opportunity to address an aspect of the causes, prevention and treatment of MSA.

Our first round of recruitment has been unable to fill this position, but we will have further details later in the year when we begin a further recruitment round in partnership with the Association of British Neurologists.

MSA Trust is looking forward to support this Fellowship and working closely with the successful applicant.

For information on the work of our current Research Fellow, Dr. Viorica Chelban, check out her articles in the magazine, MSA News, and the section on the Prospect Study, which she supports.

This study is looking for people with MSA to participate, with the aim to improve the accuracy of early diagnosis and track disease progression.

There are two elements to this, a longitudinal study based at specific clinics in London, Oxford, Cambridge, Manchester, Brighton, Newport and Newcastle – which have a strong history of supporting people with MSA. There is also an option to take part in a cross-sectional study where patients can participate from anywhere in the UK or at one of 28 UK based research centres.

The longitudinal study involves several clinical and biomarker assessments over a three year period which include: a detailed neurology review, cognitive function tests, brain scans and blood samples. This will be followed by a ‘lighter touch’ follow up over the phone or during a clinic visit for a further two years.

The cross-sectional study involves donating a one-off blood sample at your local GP or hospital, together with filling in questionnaires at home.

We would like to include people with MSA and people unaffected by neurological diseases. Since we are investigating MSA genetics, blood relatives of those affected by MSA are not eligible for the study.

Ultimately, it is hoped that the research will aid the development of new and improved treatments for MSA and raise the profile of MSA research in the UK.

If you are interested in participating in MSA research, please contact Alyssa Costantini, Research Associate, institute of Neurology, UCL –   a.costantini@ucl.ac.uk or ABN MSA Research Fellow, Viorica Chelban, UCL, v.chelban@ucl.ac.uk

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We regret to announce the MSA Trust will be suspending all of our Support Groups and our memorial event due to the outbreak of the Coronavirus Covid-19. For our full statement, please click here. Our other services and support will continue to be unaffected and available to everybody affected by MSA. For any questions please contact us at support@msatrust.org.uk.

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